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What are Runs of Homozygosity (ROH)?

A Run of Homozygosity (ROH) is a long stretch of DNA where both chromosomes carry identical alleles, because both were inherited — directly or indirectly — from the same ancestor. When a population goes through a founder event (a small group that expands) or practises endogamy (marriage within the group), everyone shares common ancestors and ROH accumulate. The longer and more numerous the segments, the more recent or intense the isolation.

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FROH — the key metric

FROH is the fraction of your autosomal genome covered by ROH >1.5 Mb. Outbred Europeans: ~0.3%. Romani: 5–8%. The higher the FROH, the more your parents share ancestry.

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Length tells you "when"

Long ROH (>10 Mb) = recent ancestor (within 5 generations). Short ROH (1–5 Mb) = ancient founder event. Formula: generations ≈ 50 ÷ length(Mb).

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Population fingerprint

Each isolated population has a characteristic profile — number, length distribution, and total SROH. This tool checks 8 known population signatures from your raw file.

Reference populations — typical FROH values

🟢Europeans (outbred)~0.3%
Baseline for non-isolated European populations. Few short ROH, no long segments, SROH typically under 10 Mb.
FROH 0.2–0.5%nROH <10No long ROH
🏔️Basque~1.2%
Pyrenean and linguistic isolation since the Mesolithic. Ancient and moderate endogamy — many short ROH, no long segments. One of the most genetically distinct European populations.
FROH 0.8–2.2%Short ROHAncient isolation
🇫🇮Finnish~1.5%
Strong Neolithic founder effect, reinforced by multiple settlement waves. Many small ROH, allele frequencies very distinct from other Europeans (Finnish disease heritage).
FROH 1.0–3.0%Founder effectShort-medium ROH
🏝️Sardinian~1.8%
Long-standing island isolation and genetic drift. Preserves strong Neolithic Anatolian ancestry. Numerous short-medium ROH reflecting ancient, not recent, isolation.
FROH 1.2–3.5%Island isolationNeolithic ancestry
✡️Ashkenazi Jewish~2.5%
Founder bottleneck ~700 years ago following expulsion from Central Europe (~5,000–10,000 founders). Many medium ROH (5–15 Mb), reflecting ~30 generations back.
FROH 1.8–4.5%~700 years agoMedium ROH
Druze~3.5%
Closed religious community since the 11th century — no outside marriage for ~40 generations. One of the highest FROH values among Middle Eastern populations.
FROH 2.5–6%Since 11th centuryLong ROH
🌾Mennonite / Amish~4.0%
Founded in the 17th–18th century by ~200–500 Anabaptists, followed by strict endogamy. Similar FROH to Ashkenazi but longer ROH — more recent and smaller founding group.
FROH 2.8–8%~300 years agoMedium-long ROH
🏜️Bedouin / Arab isolated~4.5%
Preferential cousin marriage (ibn amm) widespread in Arab tribal societies. Often very recent endogamy (1–4 generations) producing very long ROH. ROH >20 Mb = 2nd/3rd degree relatives.
FROH 3–12%Recent cousin marriageVery long ROH
🪗Romani~5.5–8%
Founder effect from departure from NW India ~1,000 years ago (estimated 200–1,000 founding individuals). Triple signal: high FROH + long ROH (>8 Mb) + South Asian admixture. Must be cross-referenced with your ancestry report.
FROH 3.5–12%~1000 years agoSouth Asian admixtureLong ROH
🕌Palestinian / Arab Muslim~2.0–4%
Levantine population with centuries of preferential cousin marriage in many communities. ROH profile can resemble Druze or Bedouin patterns without sharing those specific origins.
FROH 1.5–6%Cousin marriageMedium-long ROH
🇮🇹South Italian / Sicilian~1.0–2.2%
Rural village isolation in southern Italy (especially Calabria, Sicily, Basilicata, Abruzzo) for centuries. ROH pattern is distinct from Sardinian — less ancient, more regionally fragmented.
FROH 0.8–2.5%Village isolationShort-medium ROH
🇦🇲Armenian~1.5–3%
South Caucasian population with Neolithic continuity and centuries of community endogamy. Mix of ancient short ROH and moderate medium ROH. Distinct allele frequencies from Middle Eastern neighbours.
FROH 1.2–4.5%Caucasian isolateMixed ancient/recent ROH
🌻Hutterite~5–9%
Extreme founder effect — entire modern community descends from ~400 ancestors (18th c.). Among the highest documented FROH in any Western population. Very long, numerous ROH reflecting both founding bottleneck and ongoing endogamy.
FROH 3–10%~400 foundersLong ROH

Why can a child have less ROH than their parents? A child's ROH only appears where both parents transmitted the same haplotype inherited from a shared ancestor. If your parents come from different lineages within an endogamous community — even the same ethnic group — their ROH segments may not overlap, producing a child with lower FROH than either parent. This is the genetic equivalent of outcrossing: two endogamous people from different family lines can have a more outbred child.

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